BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

ABSTRACT Bacillus Calmette-Guerin (BCG) vaccination has been hypothesized to reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity, and/or duration via trained immunity induction. Health care workers (HCWs) in nine Dutch hospitals were randomized to BCG or placebo v...

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Bibliographic Details
Main Authors: Juana Claus, Thijs ten Doesschate, Cheyenne Gumbs, Cornelis H. van Werkhoven, Thomas W. van der Vaart, Axel B. Janssen, Gaby Smits, Rob van Binnendijk, Fiona van der Klis, Debbie van Baarle, Fernanda L. Paganelli, Helen Leavis, Lilly M. Verhagen, Simone A. Joosten, Marc J. M. Bonten, Mihai G. Netea, Janneke H. H. M. van de Wijgert
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
SARS-CoV-2
COVID-19
Bacillus Calmette-Guerin vaccine
randomized placebo-controlled clinical trial
health care workers
Online Access:https://journals.asm.org/doi/10.1128/mbio.00356-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00356-23

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