A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle

A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle

Abstract Background The 2014–2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host factors/pathways essential for the virus are advantageous because they can potentially target a wide range of viruses, incl...

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Bibliographic Details
Main Authors: Scott Martin, Abhilash I. Chiramel, Marie Luisa Schmidt, Yu-Chi Chen, Nadia Whitt, Ari Watt, Eric C. Dunham, Kyle Shifflett, Shelby Traeger, Anne Leske, Eugen Buehler, Cynthia Martellaro, Janine Brandt, Lisa Wendt, Andreas Müller, Stephanie Peitsch, Sonja M. Best, Jürgen Stech, Stefan Finke, Angela Römer-Oberdörfer, Allison Groseth, Heinz Feldmann, Thomas Hoenen
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Genome Medicine
Subjects:
Ebola virus
Carbamoyl phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase
De novo pyrimidine synthesis
Dihydroorotate dehydrogenase
Host factor
Teriflunomide
Online Access:http://link.springer.com/article/10.1186/s13073-018-0570-1

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http://link.springer.com/article/10.1186/s13073-018-0570-1

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