Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity

Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by mitochondrial dysfunction and accumulation of alpha-synuclein (α-Syn)-containing protein aggregates known as Lewy bodies (LB). Here, we investigated the entry of α-Syn into mitochondria to cause mitochondri...

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Bibliographic Details
Main Authors: Xi Zhang, Linhao Ruan, Hu Wang, Jin Zhu, Taibo Li, Gordon Sun, Yi Dong, Yuhao Wang, Gil Berreby, Ashley Shay, Rong Chen, Sreekumar Ramachandran, Valina L. Dawson, Ted M. Dawson, Rong Li
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00733-y

Internet

https://doi.org/10.1038/s41531-024-00733-y

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