Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
Abstract Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-020-0380-1 |
| _version_ | 1819179712717520896 |
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| author | Jia Yu Bo Qin Zhenkun Lou |
| author_facet | Jia Yu Bo Qin Zhenkun Lou |
| author_sort | Jia Yu |
| collection | DOAJ |
| description | Abstract Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways. |
| first_indexed | 2024-12-22T22:02:48Z |
| format | Article |
| id | doaj.art-de0c1cac5fe74056a15a301464e45d47 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-22T22:02:48Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-de0c1cac5fe74056a15a301464e45d472022-12-21T18:11:05ZengBMCCell & Bioscience2045-37012020-02-0110111010.1186/s13578-020-0380-1Ubiquitin and ubiquitin-like molecules in DNA double strand break repairJia Yu0Bo Qin1Zhenkun Lou2Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDivision of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Oncology, Mayo ClinicAbstract Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.https://doi.org/10.1186/s13578-020-0380-1Double strand breakUbiquitinUbiquitin-like proteinDNA damageDNA repair |
| spellingShingle | Jia Yu Bo Qin Zhenkun Lou Ubiquitin and ubiquitin-like molecules in DNA double strand break repair Cell & Bioscience Double strand break Ubiquitin Ubiquitin-like protein DNA damage DNA repair |
| title | Ubiquitin and ubiquitin-like molecules in DNA double strand break repair |
| title_full | Ubiquitin and ubiquitin-like molecules in DNA double strand break repair |
| title_fullStr | Ubiquitin and ubiquitin-like molecules in DNA double strand break repair |
| title_full_unstemmed | Ubiquitin and ubiquitin-like molecules in DNA double strand break repair |
| title_short | Ubiquitin and ubiquitin-like molecules in DNA double strand break repair |
| title_sort | ubiquitin and ubiquitin like molecules in dna double strand break repair |
| topic | Double strand break Ubiquitin Ubiquitin-like protein DNA damage DNA repair |
| url | https://doi.org/10.1186/s13578-020-0380-1 |
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