Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.

The genotype-phenotype correlation of MEFV remains unclear for the familial Mediterranean fever (FMF) patients, especially without canonical MEFV mutations in exon 10. The risk of FMF appeared to be under the influence of other factors in this case. The contribution of HLA polymorphisms to the risk...

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Main Authors: Michio Yasunami, Hitomi Nakamura, Kazunaga Agematsu, Akinori Nakamura, Masahide Yazaki, Dai Kishida, Akihiro Yachie, Tomoko Toma, Junya Masumoto, Hiroaki Ida, Tomohiro Koga, Atsushi Kawakami, Katsumi Eguchi, Hiroshi Furukawa, Tadashi Nakamura, Minoru Nakamura, Kiyoshi Migita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4431852?pdf=render