Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

The polyglutamine expansion in huntingtin protein causes Huntington’s disease. Here, we investigated structural and biochemical properties of huntingtin and the effect of the polyglutamine expansion using various biophysical experiments including circular dichroism, single-particle electron microsco...

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Bibliographic Details
Main Authors: Ravi Vijayvargia, Raquel Epand, Alexander Leitner, Tae-Yang Jung, Baehyun Shin, Roy Jung, Alejandro Lloret, Randy Singh Atwal, Hyeongseok Lee, Jong-Min Lee, Ruedi Aebersold, Hans Hebert, Ji-Joon Song, Ihn Sik Seong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
Huntington's disease
HEAT/HEAT-like repeat
neurodegenerative disorders
solenoid scaffold protein
Online Access:https://elifesciences.org/articles/11184

Internet

https://elifesciences.org/articles/11184

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