Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α

Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α

Varicella-zoster virus (VZV) infection of neuronal cells and the activation of cell-intrinsic antiviral responses upon infection are still poorly understood mainly due to the scarcity of suitable human in vitro models that are available to study VZV. We developed a compartmentalized human-induced pl...

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Bibliographic Details
Main Authors: Marlies Boeren, Elise Van Breedam, Tamariche Buyle-Huybrecht, Marielle Lebrun, Pieter Meysman, Catherine Sadzot-Delvaux, Viggo F. Van Tendeloo, Geert Mortier, Kris Laukens, Benson Ogunjimi, Peter Ponsaerts, Peter Delputte
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Viruses
Subjects:
varicella-zoster virus
neurons
interferon-α
interferon-stimulated genes
neuronal models
iPSC
Online Access:https://www.mdpi.com/1999-4915/14/11/2517

Internet

https://www.mdpi.com/1999-4915/14/11/2517

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