Target Trial Emulation Using Hospital-Based Observational Data: Demonstration and Application in COVID-19

Target Trial Emulation Using Hospital-Based Observational Data: Demonstration and Application in COVID-19

Methodological biases are common in observational studies evaluating treatment effectiveness. The objective of this study is to emulate a target trial in a competing risks setting using hospital-based observational data. We extend established methodology accounting for immortal time bias and time-fi...

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Bibliographic Details
Main Authors: Oksana Martinuka, Maja von Cube, Derek Hazard, Hamid Reza Marateb, Marjan Mansourian, Ramin Sami, Mohammad Reza Hajian, Sara Ebrahimi, Martin Wolkewitz
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Life
Subjects:
competing events
COVID-19
methodology
observational data
target trial emulation
Online Access:https://www.mdpi.com/2075-1729/13/3/777

Internet

https://www.mdpi.com/2075-1729/13/3/777

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