Targeting Anti-Angiogenic VEGF<sub>165</sub>b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease Models

Targeting Anti-Angiogenic VEGF<sub>165</sub>b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease Models

Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A over-expression nor L-Arginine (NO-precursor) supplementation has been effective in helping patients with Peripheral Artery Disease (PAD) in clinical trials. One incompletely studied reason may be due to the p...

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Bibliographic Details
Main Authors: Sivaraman Kuppuswamy, Brian H. Annex, Vijay C. Ganta
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
angiogenesis
anti-angiogenic VEGF-A
ischemia
growth factor signaling
nitric oxide
diabetes
Online Access:https://www.mdpi.com/2073-4409/11/17/2676

Internet

https://www.mdpi.com/2073-4409/11/17/2676

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