SAR131675, a VEGRF3 Inhibitor, Modulates the Immune Response and Reduces the Growth of Colorectal Cancer Liver Metastasis

SAR131675, a VEGRF3 Inhibitor, Modulates the Immune Response and Reduces the Growth of Colorectal Cancer Liver Metastasis

Most patients with colorectal cancer (CRC) develop metastases, predominantly in the liver (CLM). Targeted therapies are being investigated to improve current CLM treatments. This study tested the effectiveness of SAR131675, a selective VEGFR-3 tyrosine kinase inhibitor, to inhibit CLM in a murine mo...

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Bibliographic Details
Main Authors: Katrina A. Walsh, Georgios Kastrappis, Theodora Fifis, Rita Paolini, Christopher Christophi, Marcos V. Perini
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
colorectal cancer
liver metastases
tyrosine kinase
VEGFR3
lymphangiogenesis
myeloid derived suppressor cells
Online Access:https://www.mdpi.com/2072-6694/14/11/2715

Internet

https://www.mdpi.com/2072-6694/14/11/2715

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