Speckle-type POZ protein could play a potential inhibitory role in human renal cell carcinoma

Speckle-type POZ protein could play a potential inhibitory role in human renal cell carcinoma

Abstract Background Speckle-type POZ protein(SPOP), a substrate adaptor of Cul3 ubiquitin ligase, plays crucial roles in solid neoplasms by promoting the ubiquitination and degradation of substrates. Limited studies have shown that SPOP is overexpressed in human renal cell carcinoma (RCC) tissue. Ho...

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Bibliographic Details
Main Authors: Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin, Wei Li
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
Renal cell carcinoma
Speckle-type POZ protein
In vitro proliferation
Migration
Invasion
Apoptosis
Online Access:https://doi.org/10.1186/s12885-022-10340-w

Internet

https://doi.org/10.1186/s12885-022-10340-w

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