Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer

Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer

Integrins contribute to cancer progression and aggressiveness by activating intracellular signal transduction pathways and transducing mechanical tension forces. Remarkably, these adhesion receptors share common signaling networks with receptor tyrosine kinases (RTKs) and support their oncogenic act...

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Bibliographic Details
Main Authors: Elisabete Cruz da Silva, Monique Dontenwill, Laurence Choulier, Maxime Lehmann
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
integrin
focal adhesion kinase
therapy resistance
tyrosine kinase inhibitors
cancer-associated fibroblasts
mechanotransduction
EGFR
c-MET
Online Access:https://www.mdpi.com/2072-6694/11/5/692

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https://www.mdpi.com/2072-6694/11/5/692

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