Quantification of tumour-infiltrating immune cells through deconvolution of DNA methylation data in Ewing sarcomas

Quantification of tumour-infiltrating immune cells through deconvolution of DNA methylation data in Ewing sarcomas

Ewing Sarcomas (EWS, OMIM#612219) presents a major challenge in pediatric oncology due to its aggressive nature and poor prognosis, particularly in metastatic cases. Genetic fusions involving the EWSR1 gene and ETS family transcription factors are common in EWS, though other rarer fusions have also...

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Bibliographic Details
Main Authors: Sara Patrizi, Silvia Vallese, Lucia Pedace, Claudia Nardini, Alessandra Stracuzzi, Sabina Barresi, Isabella Giovannoni, Luana Abballe, Celeste Antonacci, Ida Russo, Angela Di Giannatale, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Epigenetics and Epigenomics
Subjects:
Ewing sarcoma
DNA methylation
immune microenvironment
deconvolution
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/freae.2024.1427399/full

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https://www.frontiersin.org/articles/10.3389/freae.2024.1427399/full

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