The Influenza Virus RNA-Polymerase and the Host RNA-Polymerase II: RPB4 Is Targeted by a PB2 Domain That Is Involved in Viral Transcription

The Influenza Virus RNA-Polymerase and the Host RNA-Polymerase II: RPB4 Is Targeted by a PB2 Domain That Is Involved in Viral Transcription

Influenza virus transcription is catalyzed by the viral RNA-polymerase (FluPol) through a cap-snatching activity. The snatching of the cap of cellular mRNA by FluPol is preceded by its binding to the flexible C-terminal domain (CTD) of the RPB1 subunit of RNA-polymerase II (Pol II). To better unders...

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Bibliographic Details
Main Authors: Jessica Morel, Laura Sedano, Nathalie Lejal, Bruno Da Costa, Eric Batsché, Christian Muchardt, Bernard Delmas
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
influenza virus
RNA-polymerase
RNA-polymerase II
protein-protein interaction
PPI
cap snatching
Online Access:https://www.mdpi.com/1999-4915/14/3/518

Internet

https://www.mdpi.com/1999-4915/14/3/518

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