Cell fate in colon cancer stem cells: To GLI or not to GLI?*
Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs). We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Molecular & Cellular Oncology |
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| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1445940 |