An active fraction from Spatholobus suberectus dunn inhibits the inflammatory response by regulating microglia activation, switching microglia polarization from M1 to M2 and suppressing the TLR4/MyD88/NF-κB pathway in LPS-stimulated BV2 cells

An active fraction from Spatholobus suberectus dunn inhibits the inflammatory response by regulating microglia activation, switching microglia polarization from M1 to M2 and suppressing the TLR4/MyD88/NF-κB pathway in LPS-stimulated BV2 cells

Neurodegenerative disorders are known to be associated with neuroinflammation caused by microglia. Therefore, regulation of microglia activation and polarization to inhibit neuroinflammatory reactions seems to hold promise as a therapeutic approach in neurodegenerative disorders. Spatholobus suberec...

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Bibliographic Details
Main Authors: Molu Ban, Hua Su, Xianbiao Zeng, Chunxia Chen, Shuguang Zhou, Xiaoyu Chen, Zhihuan Nong
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Neuroinflammation
Neurodegenerative disorders
Microglia
ASSD
TLR4/MyD88/NF-κB pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023021862

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http://www.sciencedirect.com/science/article/pii/S2405844023021862

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