The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules. ERAP1 has unique properties for an aminopeptidase being able to trim peptides in vit...

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Bibliographic Details
Main Authors: Irini Evnouchidou, Frank Momburg, Athanasios Papakyriakou, Angeliki Chroni, Leondios Leondiadis, Shih-Chung Chang, Alfred L Goldberg, Efstratios Stratikos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2573961?pdf=render

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http://europepmc.org/articles/PMC2573961?pdf=render

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