Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 Subline

Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 Subline

Aim: To establish a p53-negative osteosarcoma (OS) SaOS-2 cellular subline exhibiting resistance to specific chemotherapeutic agents, including topoisomerase II inhibitors, taxanes, and vinca alkaloids. Methods: The OS subline exhibiting resistance to the chemotherapeutic agents indicated above was...

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Bibliographic Details
Main Authors: Sergei Boichuk, Firyuza Bikinieva, Elena Valeeva, Pavel Dunaev, Maria Vasileva, Pavel Kopnin, Ekaterina Mikheeva, Tatyana Ivoilova, Ilshat Mustafin, Aigul Galembikova
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Diagnostics
Subjects:
Osteosarcoma (OS)
ABC-transporters
paclitaxel
doxorubicin
resistance
apoptosis
Online Access:https://www.mdpi.com/2075-4418/13/16/2646

Internet

https://www.mdpi.com/2075-4418/13/16/2646

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