Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Abstract Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the endotheliu...

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Bibliographic Details
Main Authors: Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Molecular Medicine
Subjects:
Hypertension
Acetylcholine
Choline acetyltransferase
PEG-ChAT
Online Access:https://doi.org/10.1186/s10020-021-00380-6

Internet

https://doi.org/10.1186/s10020-021-00380-6

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