Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Abstract Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the endotheliu...

Full description

Bibliographic Details
Main Authors:	Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Format:	Article
Language:	English
Published:	BMC 2021-10-01
Series:	Molecular Medicine
Subjects:	Hypertension Acetylcholine Choline acetyltransferase PEG-ChAT
Online Access:	https://doi.org/10.1186/s10020-021-00380-6

Similar Items

Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice
by: Nguyen Khanh Toan, et al.
Published: (2021-01-01)

A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon
by: Jean-Pierre Bellier, et al.
Published: (2019-04-01)

Immunolocalization of choline acetyltransferase of common type in the central brain mass of Octopus vulgaris
by: A. Casini, et al.
Published: (2012-07-01)

Repeated Intravenous Administration of Human Neural Stem Cells Producing Choline Acetyltransferase Exerts Anti-Aging Effects in Male F344 Rats
by: Jangbeen Kyung, et al.
Published: (2023-11-01)

ACETYLCHOLINE AND ITS SYNTHESIZING ENZYME CHOLINE ACETYLTRANSPHERASE IN THE ENTERIC NERVOUS SYSTEM
by: Desislava M. Marinova, et al.
Published: (2022-11-01)

Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca2+ transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice.
by: Tobias eMühling, et al.
Published: (2014-11-01)

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
by: Namrita Halder, et al.
Published: (2021-04-01)

Evaluation of the Activity of Choline Acetyltransferase From Different Synaptosomal Fractions at the Distinct Stages of Spatial Learning in the Morris Water Maze
by: Zinaida I. Storozheva, et al.
Published: (2021-10-01)

Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model
by: Minsook Ye, et al.
Published: (2020-07-01)

Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost Cyprinus carpio
by: Arianna Casini, et al.
Published: (2018-07-01)

Ocimum sanctum Linn. stimulate the expression of choline acetyltransferase on the human cerebral microvascular endothelial cells
by: Dwi Liliek Kusindarta, et al.
Published: (2016-12-01)

Chronic dietary ginseng extract administration ameliorates antioxidant and cholinergic systems in the brains of aged mice
by: Mi Ra Lee, et al.
Published: (2017-10-01)

Cholinergic Projections From the Pedunculopontine Tegmental Nucleus Contact Excitatory and Inhibitory Neurons in the Inferior Colliculus
by: William A. Noftz, et al.
Published: (2020-07-01)

Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: a pilot study
by: Rocío E. González-Castañeda, et al.
Published: (2013-01-01)

Expression of Cholinergic Markers and Characterization of Splice Variants during Ontogenesis of Rat Dorsal Root Ganglia Neurons
by: Veronica Corsetti, et al.
Published: (2021-05-01)

ON THE BIOLOGICAL ROLE OF CHOLINE IN HUMAN AND HIGHER ANIMAL ORGANISMS (A LITERATURE REVIEW)
by: Roman A. Bekker, et al.
Published: (2021-10-01)

Enhancing effect of Tiliacora triandra leaves extract on spatial learning, memory and learning flexibility as well as hippocampal choline acetyltransferase activity in mice
by: Wachiryah Thong-asa, et al.
Published: (2018-06-01)

Effects of Smart Drugs on Cholinergic System and Non-Neuronal Acetylcholine in the Mouse Hippocampus: Histopathological Approach
by: Ryusei Satoh, et al.
Published: (2022-06-01)

Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype
by: Fulton T. Crews, et al.
Published: (2022-08-01)

Adult islet1 Expression Outlines Ventralized Derivatives Along Zebrafish Neuraxis
by: Stephan W. Baeuml, et al.
Published: (2019-02-01)

LC–MS/MS Analysis of Choline Compounds in Japanese-Cultivated Vegetables and Fruits
by: Wenhao Wang, et al.
Published: (2020-07-01)

Choline derivatives as natural ligands of mitochondrial nicotinic acetylcholine receptors
by: O. Lykhmus, et al.
Published: (2023-04-01)

Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP
by: Trevor M. Morey, et al.
Published: (2017-12-01)

Cholinergic forebrain degeneration in the APPswe/PS1ΔE9 transgenic mouse
by: Sylvia E. Perez, et al.
Published: (2007-10-01)

Biomolecular Evaluation of <i>Lavandula stoechas</i> L. for Nootropic Activity
by: Aamir Mushtaq, et al.
Published: (2021-06-01)

A comparison of the distribution and morphology of ChAT-, VAChT-immunoreactive and AChE-positive neurons in the thoracolumbar and sacral spinal cord of the pig
by: J. Calka, et al.
Published: (2008-08-01)

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex
by: Laura Tarnawski, et al.
Published: (2018-11-01)

Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit
by: Marcelo J. Moglie, et al.
Published: (2021-02-01)

Rosiridin Attenuates Scopolamine-Induced Cognitive Impairments in Rats via Inhibition of Oxidative and Nitrative Stress Leaded Caspase-3/9 and TNF-α Signaling Pathways
by: Muhammad Afzal, et al.
Published: (2022-09-01)

GLP-2 Prevents Neuronal and Glial Changes in the Distal Colon of Mice Chronically Treated with Cisplatin
by: Patrizia Nardini, et al.
Published: (2020-11-01)

CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment
by: Azadeh Karami, et al.
Published: (2021-08-01)

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers
by: Sumonto Mitra, et al.
Published: (2021-08-01)

Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Aβ Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice
by: Dongsun Park, et al.
Published: (2020-05-01)

Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T Leukemia
by: Oxana Dobrovinskaya, et al.
Published: (2016-08-01)

Alzheimer's disease biomarker discovery using <it>in silico</it> literature mining and clinical validation
by: Greco Ines, et al.
Published: (2012-10-01)

Choline supplements: An update
by: Urna Kansakar, et al.
Published: (2023-03-01)

Progress of Acetyltransferase Gene Naa10 in Cancer
by: HE Zukun, et al.
Published: (2019-01-01)

CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer’s disease in the Czech population
by: Alice Hálová, et al.
Published: (2018-05-01)

Mesencephalic Electrical Stimulation Reduces Neuroinflammation after Photothrombotic Stroke in Rats by Targeting the Cholinergic Anti-Inflammatory Pathway
by: Michael K. Schuhmann, et al.
Published: (2021-01-01)

Blocking Muscarinic Receptor 3 Attenuates Tumor Growth and Decreases Immunosuppressive and Cholinergic Markers in an Orthotopic Mouse Model of Colorectal Cancer
by: Nyanbol Kuol, et al.
Published: (2022-12-01)