Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel

Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel

The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC). Inhibition of OGT serves as a potential strategy for PC treatment alone or combinational therapy. PC is the second common cancer...

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Bibliographic Details
Main Authors: Mingyue Xia, Shuyan Wang, Yannan Qi, Kaili Long, Enjie Li, Lingfeng He, Feiyan Pan, Zhigang Guo, Zhigang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
OGT
chemotherapy
docetaxel
miR-140
prostate cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.993243/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.993243/full

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