Mineralocorticoid Receptor Antagonism Attenuates Multiple Organ Failure after Renal Ischemia and Reperfusion in Mice

Mineralocorticoid Receptor Antagonism Attenuates Multiple Organ Failure after Renal Ischemia and Reperfusion in Mice

Renal ischemia reperfusion (IR) injury is a major cause of acute kidney injury (AKI) that is often complicated by multiple organ failure of the liver and intestine. The mineralocorticoid receptor (MR) is activated in patients with renal failure associated with glomerular and tubular damage. We thus...

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Bibliographic Details
Main Authors: Eun Jung Park, Jihyun Je, Theodomir Dusabimana, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
renal ischemia reperfusion injury
acute kidney injury
mineralocorticoid receptor
aldosterone
multiple organ failure
Online Access:https://www.mdpi.com/1422-0067/24/4/3413

Internet

https://www.mdpi.com/1422-0067/24/4/3413

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