The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma

The immunoglobulin (Ig) heavy and light chain variable gene mutational pattern of the B cell receptor (BCR) in primary central nervous system (CNS) lymphoma (PCNSL) cells suggests antigenic selection to drive pathogenesis and confinement to the CNS. This hypothesis is supported by the observation t...

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Bibliographic Details
Main Authors: Manuel Montesinos-Rongen, Monica Terrao, Caroline May, Katrin Marcus, Ingmar Blümcke, Martin Hellmich, Ralf Küppers, Anna Brunn, Martina Deckert
Format: Article
Language:English
Published: Ferrata Storti Foundation 2020-03-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/9693

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https://haematologica.org/article/view/9693

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