Formulation and Optimization of Metronidazole and <i>Lactobacillus</i> spp. Layered Suppositories via a Three-Variable, Five-Level Central Composite Design for the Management of Bacterial Vaginosis

Formulation and Optimization of Metronidazole and <i>Lactobacillus</i> spp. Layered Suppositories via a Three-Variable, Five-Level Central Composite Design for the Management of Bacterial Vaginosis

Bacterial vaginosis, a polymicrobial clinical syndrome characterized by a shift in healthy vaginal microbiota due to bacterial colonization, is characterized by high recurrence rates after conventional treatment with an antimicrobial agent. This has necessitated the need to develop a formulation tha...

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Bibliographic Details
Main Authors: Margaret O. Ilomuanya, Busayo B. Salako, Modupe O. Ologunagba, Omonike O. Shonekan, Kruga Owodeha-Ashaka, Eseosa S. Osahon, Andrew N. Amenaghawon
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
central composite design
bacterial vaginosis
layered suppositories
<i>Lactobacillus</i> spp.
Online Access:https://www.mdpi.com/1999-4923/14/11/2337

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https://www.mdpi.com/1999-4923/14/11/2337

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