The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations

The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations

Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the contribution of rare variants in PRSs to predict disea...

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Main Authors: Zhe Wang, Shing Wan Choi, Nathalie Chami, Eric Boerwinkle, Myriam Fornage, Susan Redline, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Wonji Kim, Merry-Lynn N. McDonald, Elizabeth A. Regan, Edwin K. Silverman, Ching-Ti Liu, Ramachandran S. Vasan, Rita R. Kalyani, Rasika A. Mathias, Lisa R. Yanek, Donna K. Arnett, Anne E. Justice, Kari E. North, Robert Kaplan, Susan R. Heckbert, Mariza de Andrade, Xiuqing Guo, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Patrick T. Ellinor, Steven A. Lubitz, John Blangero, M. Benjamin Shoemaker, Dawood Darbar, Mark T. Gladwin, Christine M. Albert, Daniel I. Chasman, Rebecca D. Jackson, Charles Kooperberg, Alexander P. Reiner, Paul F. O’Reilly, Ruth J. F. Loos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Endocrinology
Subjects:
polygenic risk score
rare variants
obesity risk
burden score
PRS-CS
lassosum
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.863893/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.863893/full

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