Alterations in the gut microbiome and metabolome profiles of septic rats treated with aminophylline

Abstract The treatment of sepsis remains a major challenge worldwide. Aminophylline has been shown to have anti-inflammatory effects; however, the role of aminophylline in sepsis, a disease characterized by immune dysregulation, is unknown. In this study, we combined microbiome sequencing and metabo...

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Bibliographic Details
Main Authors: Yuanzhe Li, Huayan Zhao, Guiying Sun, Yongtao Duan, Yanjun Guo, Lina Xie, Xianfei Ding
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-022-03280-3