CXCR3+ T Follicular Helper Cells Induced by Co-Administration of RTS,S/AS01B and Viral-Vectored Vaccines Are Associated With Reduced Immunogenicity and Efficacy Against Malaria

CXCR3+ T Follicular Helper Cells Induced by Co-Administration of RTS,S/AS01B and Viral-Vectored Vaccines Are Associated With Reduced Immunogenicity and Efficacy Against Malaria

A malaria vaccine strategy targeting multiple lifecycle stages may be required to achieve a high level of efficacy. In two Phase IIa clinical trials, we tested immunogenicity and efficacy of RTS,S/AS01B administered alone, in a staggered regimen with viral-vectored vaccines or co-administered with v...

Full description

Bibliographic Details
Main Authors: Georgina Bowyer, Amy Grobbelaar, Tommy Rampling, Navin Venkatraman, Danielle Morelle, Ripley W. Ballou, Adrian V. S. Hill, Katie J. Ewer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
malaria
vaccine
T follicular helper cell
antibody
efficacy
CXCR3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01660/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01660/full

Similar Items