A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

Abstract Background Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-la...

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Bibliographic Details
Main Authors: Lia Gore, Timothy J. Triche, Jason E. Farrar, Daniel Wai, Christophe Legendre, Gerald C. Gooden, Winnie S. Liang, John Carpten, David Lee, Frank Alvaro, Margaret E. Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran, Jessica Pollard, Soheil Meshinchi, Jessica Boklan, Robert J. Arceci, Bodour Salhia
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Clinical Epigenetics
Subjects:
AML
Epigenetics
Pediatrics
Pharmacokinetics
Pharmacodynamics
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s13148-017-0411-x

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http://link.springer.com/article/10.1186/s13148-017-0411-x

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