Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme

Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme

β-thalassemia is a genetic hemoglobin (Hb) disorder that affects millions of people world-wide. It is characterized by ineffective erythropoiesis and anemia. The resultant chronic anemia can require life-long blood transfusion regimens, leading to secondary hemochromatosis. Moreover, the abnormal re...

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Bibliographic Details
Main Authors: Carlos J. Munoz, Ivan S. Pires, Vinay Jani, Srila Gopal, Andre F. Palmer, Pedro Cabrales
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Apohemoglobin
Haptoglobin
Iron toxicity
Thalassemia
Anemia
Hemolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013002

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http://www.sciencedirect.com/science/article/pii/S0753332222013002

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