Unfolding Protein-Based Hapten Coupling via Thiol–Maleimide Click Chemistry: Enhanced Immunogenicity in Anti-Nicotine Vaccines Based on a Novel Conjugation Method and MPL/QS-21 Adjuvants

Unfolding Protein-Based Hapten Coupling via Thiol–Maleimide Click Chemistry: Enhanced Immunogenicity in Anti-Nicotine Vaccines Based on a Novel Conjugation Method and MPL/QS-21 Adjuvants

Vaccines typically work by eliciting an immune response against larger antigens like polysaccharides or proteins. Small molecules like nicotine, on their own, usually cannot elicit a strong immune response. To overcome this, anti-nicotine vaccines often conjugate nicotine molecules to a carrier prot...

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Bibliographic Details
Main Authors: Ying Xu, Huiting Li, Xiongyan Meng, Jing Yang, Yannan Xue, Changcai Teng, Wenxin Lv, Zhen Wang, Xiaodan Li, Tiantian Sun, Shuai Meng, Chengli Zong
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Polymers
Subjects:
immunopharmacotherapy
anti-nicotine vaccine
unfolding protein
organic phase conjugation
thiol–maleimide click chemistry
Online Access:https://www.mdpi.com/2073-4360/16/7/931

Internet

https://www.mdpi.com/2073-4360/16/7/931

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