Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming

Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming

Summary: Endothelial cell (EC) metabolism has emerged as a driver of angiogenesis. While hypoxia inactivates the oxygen sensors prolyl-4 hydroxylase domain-containing proteins 1–3 (PHD1-3) and stimulates angiogenesis, the effects of PHDs on EC functions remain poorly defined. Here, we investigated t...

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Bibliographic Details
Main Authors: Ratnakar Tiwari, Prashant V. Bommi, Peng Gao, Matthew J. Schipma, Yalu Zhou, Susan E. Quaggin, Navdeep S. Chandel, Pinelopi P. Kapitsinou
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
Metabolomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422201358X

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http://www.sciencedirect.com/science/article/pii/S258900422201358X

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