Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice

Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice

Huntington’s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without effective therapy. Evidence suggests that lifestyle factors can modulate disease onset and progression, and environmental enrichment (EE) has emerged as a...

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Bibliographic Details
Main Authors: Evelini Plácido, Priscilla Gomes Welter, Ana Wink, Gabriela Duarte Karasiak, Tiago Fleming Outeiro, Alcir Luiz Dafre, Joana Gil-Mohapel, Patricia S. Brocardo
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
environmental enrichment
Huntington’s disease
monoamines
neurodegeneration
neuronal plasticity
transgenic animal model
Online Access:https://www.mdpi.com/1422-0067/24/16/12607

Internet

https://www.mdpi.com/1422-0067/24/16/12607

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