Cigarette smoke stimulates clonal expansion of Jak2V617F and Tet2-/- cells

Cigarette smoke stimulates clonal expansion of Jak2V617F and Tet2-/- cells

IntroductionSomatic mutations in myeloid growth factor pathway genes, such as JAK2, and genes involved in epigenetic regulation, such as TET2, in hematopoietic stem cells (HSCs) leads to clonal hematopoiesis of indeterminate potential (CHIP) which presents a risk factor for hematologic malignancy an...

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Bibliographic Details
Main Authors: Gajalakshmi Ramanathan, Jane H. Chen, Nitya Mehrotra, Tiffany Trieu, Aaron Huang, Eduard Mas, Jessica E. Monterrosa Mena, Bishop Bliss, David A. Herman, Michael T. Kleinman, Angela G. Fleischman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
inflammation
myeloproliferative neoplasm
reactive oxygen species
cigarette smoke
clonal hematopoiesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1210528/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1210528/full

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