Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver...

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Bibliographic Details
Main Authors: He Bai, Jian Wen, Jian-Ping Gong, Hao Wu, Fang-Chao Yuan, Ding Cao, Ya-Kun Wu, Xing Lai, Meng-Hao Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-05-01
Series:Autoimmunity
Subjects:
orthotopic liver transplantation
kupffer cells
notch1/jagged1 pathway
ischemia-reperfusion injury
Online Access:http://dx.doi.org/10.1080/08916934.2019.1637424

Internet

http://dx.doi.org/10.1080/08916934.2019.1637424

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