Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3–5 years of diagnosis. Recently, we identified disease-linked mutations in the CCNF gene, which encodes the cycl...

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Bibliographische Detailangaben
Hauptverfasser: Albert Lee, Stephanie L. Rayner, Alana De Luca, Serene S. L. Gwee, Marco Morsch, Vinod Sundaramoorthy, Hamideh Shahheydari, Audrey Ragagnin, Bingyang Shi, Shu Yang, Kelly L. Williams, Emily K. Don, Adam K. Walker, Katharine Y. Zhang, Justin J. Yerbury, Nicholas J. Cole, Julie D. Atkin, Ian P. Blair, Mark P. Molloy, Roger S. Chung
Format: Artikel
Sprache:English
Veröffentlicht: The Royal Society 2017-01-01
Schriftenreihe:Open Biology
Schlagworte:
ubiquitylation
phosphorylation
ccnf
cyclin f
amyotrophic lateral sclerosis
frontotemporal dementia
Online Zugang:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170058

Online

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170058

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