Kinetic modelling of GlmU reactions - prioritization of reaction for therapeutic application.

Mycobacterium tuberculosis(Mtu), a successful pathogen, has developed resistance against the existing anti-tubercular drugs necessitating discovery of drugs with novel action. Enzymes involved in peptidoglycan biosynthesis are attractive targets for antibacterial drug discovery. The bifunctional enz...

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Bibliographic Details
Main Authors: Vivek K Singh, Kaveri Das, Kothandaraman Seshadri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3428340?pdf=render