A genetic selection for Mycobacterium smegmatis mutants tolerant to killing by sodium citrate defines a combined role for cation homeostasis and osmotic stress in cell death

A genetic selection for Mycobacterium smegmatis mutants tolerant to killing by sodium citrate defines a combined role for cation homeostasis and osmotic stress in cell death

ABSTRACT Mycobacteria can colonize environments where the availability of metal ions is limited. Biological or inorganic chelators play an important role in limiting metal availability, and we developed a model to examine Mycobacterium smegmatis survival in the presence of the chelator sodium citrat...

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Bibliographic Details
Main Authors: John T. Williams, Jacob J. Baker, Huiqing Zheng, Shelby J. Dechow, Jared Fallon, Megan Murto, Veronica J. Albrecht, Haleigh N. Gilliland, Andrew J. Olive, Robert B. Abramovitch
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mSphere
Subjects:
Mycobacterium
stress response
metals
Online Access:https://journals.asm.org/doi/10.1128/msphere.00358-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00358-23

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