AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway

AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway

Abstract Objective To elucidate the mechanism whereby advanced glycation end products (AGEs) accelerate atherosclerosis (AS) and to explore novel therapeutic strategies for atherosclerotic cardiovascular disease. Methods and results The effect of AGEs on low-density lipoprotein (LDL) transcytosis ac...

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Bibliographic Details
Main Authors: Meng Shu, Wenzhuo Cheng, Xiong Jia, Xiangli Bai, Ying Zhao, Yajing Lu, Lin Zhu, Yan Zhu, Li Wang, Yan Shu, Yi Song, Si Jin
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Medicine
Subjects:
AGEs
RAGE
Diabetic atherosclerosis
Caveolin-1
LDL transcytosis
Online Access:https://doi.org/10.1186/s10020-023-00715-5

Internet

https://doi.org/10.1186/s10020-023-00715-5

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