Fasudil Increased the Sensitivity to Gefitinib in NSCLC by Decreasing Intracellular Lipid Accumulation

Fasudil Increased the Sensitivity to Gefitinib in NSCLC by Decreasing Intracellular Lipid Accumulation

Tyrosine kinase inhibitors (TKIs) resistance is a challenge in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC). Here, we examined the effect of Fasudil in reversing TKIs resistance. The results of CCK8 assay, clone formation assay, cell cycle arrest an...

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Bibliographic Details
Main Authors: Tingting Liao, Jingjing Deng, Wenjuan Chen, Juanjuan Xu, Guanghai Yang, Mei Zhou, Zhilei Lv, Sufei Wang, Siwei Song, Xueyun Tan, Zhengrong Yin, Yumei Li, Yang Jin
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
Fasudil
EGFR
NSCLC
gefitinib
lipid metabolism
Online Access:https://www.mdpi.com/2072-6694/14/19/4709

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https://www.mdpi.com/2072-6694/14/19/4709

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