Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis

Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis

Abstract Background Cardiac fibrosis is one of the top killers among fibrotic diseases and continues to be a global unaddressed health problem. The lack of effective treatment combined with the considerable socioeconomic burden highlights the urgent need for innovative therapeutic options. Here, we...

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Bibliographic Details
Main Authors: Milena Paw, Agnieszka A. Kusiak, Kinga Nit, Jacek J. Litewka, Marcin Piejko, Dawid Wnuk, Michał Sarna, Kinga Fic, Kinga B. Stopa, Ruba Hammad, Olga Barczyk-Woznicka, Toni Cathomen, Ewa Zuba-Surma, Zbigniew Madeja, Paweł E. Ferdek, Sylwia Bobis-Wozowicz
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Medicine
Subjects:
Extracellular vesicles
Induced pluripotent stem cells
Hypoxia
Low oxygen
Heart fibrosis
Therapy
Online Access:https://doi.org/10.1186/s12916-023-03117-w

Internet

https://doi.org/10.1186/s12916-023-03117-w

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