The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Abstract Background Multiple trials have attempted to demonstrate the effective induction of cell death in TRAIL-resistant cancer cells, including using a combined treatment of recombinant TRAIL and various proteasome inhibitors. These studies have yielded limited success, as the mechanism of cell d...

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Bibliographic Details
Main Authors: Sunhyo Ryu, Yun Jeong Ahn, Chakeong Yoon, Jeong Hwan Chang, Yoonkyung Park, Tae-Hyoung Kim, Amanda R. Howland, Cheryl A. Armstrong, Peter I. Song, Ae Ran Moon
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Recombinant TRAIL
Bortezomib
Combination treatment
Caspase-dependent
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4352-3

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http://link.springer.com/article/10.1186/s12885-018-4352-3

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