The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor...

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Bibliographic Details
Main Authors: Xiu Lv, Jincheng Li, Chuhong Zhang, Tian Hu, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen, Jianhong Zuo
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-03-01
Series:Genes and Diseases
Subjects:
Angiogenesis
HIF
Hypoxia
Metabolism
VHL
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304216300721

Internet

http://www.sciencedirect.com/science/article/pii/S2352304216300721

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