Diffuse large B-cell lymphoma: the significance of CD8+ tumor-infiltrating lymphocytes exhaustion mediated by TIM3/Galectin-9 pathway

Diffuse large B-cell lymphoma: the significance of CD8+ tumor-infiltrating lymphocytes exhaustion mediated by TIM3/Galectin-9 pathway

Abstract Background Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, the mechanism of TIM3-mediated CD8+TILs exhaustion in DLBCL remains p...

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Bibliographic Details
Main Authors: Qiqi Zhu, Yiming Yang, Kexin Chen, Qiaoyu Zhang, Yifan Huang, Shunhai Jian
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Diffuse large B-cell lymphoma
CD8+ tumor-infiltrating lymphocytes
TIM3/Galectin-9 pathway
Exhaustion
Immune checkpoint
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s12967-024-05002-3

Internet

https://doi.org/10.1186/s12967-024-05002-3

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