Enhanced production of Chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line.

Enhanced production of Chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line.

Chikungunya virus-like particles (VLPs) have potential to be used as a prophylactic vaccine based on testing in multiple animal models and are currently being evaluated for human use in a Phase I clinical trial. The current method for producing these enveloped alphavirus VLPs by transient gene expre...

Full description

Bibliographic Details
Main Authors: James M Wagner, J David Pajerowski, Christopher L Daniels, Patrick M McHugh, Jessica A Flynn, John W Balliet, Danilo R Casimiro, Shyamsundar Subramanian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094401&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094401&type=printable

Similar Items