ONC201-Induced Mitochondrial Dysfunction, Senescence-like Phenotype, and Sensitization of Cultured BT474 Human Breast Cancer Cells to TRAIL

ONC201-Induced Mitochondrial Dysfunction, Senescence-like Phenotype, and Sensitization of Cultured BT474 Human Breast Cancer Cells to TRAIL

ONC201, the anticancer drug, targets and activates mitochondrial ATP-dependent caseinolytic peptidase P (ClpP), a serine protease located in the mitochondrial matrix. Given the promise of ONC201 in cancer treatment, we evaluated its effects on the breast ductal carcinoma cell line (BT474). We showed...

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Bibliographic Details
Main Authors: Artem Mishukov, Irina Odinokova, Ekaterina Mndlyan, Margarita Kobyakova, Serazhutdin Abdullaev, Vitaly Zhalimov, Xenia Glukhova, Vasiliy Galat, Yekaterina Galat, Anatoly Senotov, Roman Fadeev, Artem Artykov, Marine E. Gasparian, Marina Solovieva, Igor Beletsky, Ekhson Holmuhamedov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
ONC201
BT474
mtDNA
changes in the surface proteins expression
senescence
NK-mediated killing of BT474 cells
Online Access:https://www.mdpi.com/1422-0067/23/24/15551

Internet

https://www.mdpi.com/1422-0067/23/24/15551

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