SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation

SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation

Abstract Background Acute myeloid leukemia (AML) is characterized by accumulation of aberrantly differentiated hematopoietic myeloid progenitor cells. The karyotyping-silent NUP98-NSD1 fusion is a molecular hallmark of pediatric AML and is associated with the activating FLT3-ITD mutation in > 70%...

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Bibliographic Details
Main Authors: Zivojin Jevtic, Vittoria Matafora, Francesca Casagrande, Fabio Santoro, Saverio Minucci, Massimilliano Garre’, Milad Rasouli, Olaf Heidenreich, Giovanna Musco, Jürg Schwaller, Angela Bachi
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
NUP98-NSD1
SMARCA5
Acute myeloid leukemia
Phase-separation
Interactomics
Online Access:https://doi.org/10.1186/s13046-022-02248-x

Internet

https://doi.org/10.1186/s13046-022-02248-x

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