Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes.

Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes.

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer in the United States, affecting one million people per year. Patients with aggressive disease have limited treatment options and high mortality, highlighting the need to identify new biomarkers linked to poor clin...

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Bibliographic Details
Main Authors: Mary B Kelley, Taylor J Geddes, Maria Ochiai, Noah M Lampl, W Wade Kothmann, Sara R Fierstein, Victoria Kent, Kathleen DeCicco-Skinner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0266017

Internet

https://doi.org/10.1371/journal.pone.0266017

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