Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma

Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma

Abstract The response to programmed death-1 (PD-1) blockade varies in hepatocellular carcinoma (HCC). We utilize a panel of 16 serum factors to show that a circulating level of serum amyloid A (SAA) > 20.0 mg/L has the highest accuracy in predicting anti-PD-1 resistance in HCC. Further experiment...

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Main Authors: Meng He, Yongxiang Liu, Song Chen, Haijing Deng, Cheng Feng, Shuang Qiao, Qifeng Chen, Yue Hu, Huiming Chen, Xun Wang, Xiongying Jiang, Xiaojun Xia, Ming Zhao, Ning Lyu
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46118-w

Internet

https://doi.org/10.1038/s41467-024-46118-w

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