Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Abstract Characterizing the HIV-1 reservoir in blood and tissues is crucial for the development of curative strategies. Using an HIV Tat mRNA-containing lipid nanoparticle (Tat-LNP) in combination with panobinostat, we show that p24+ cells from blood and lymph nodes exhibit distinct phenotypes. Bloo...

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Bibliographic Details
Main Authors: Marion Pardons, Laurens Lambrechts, Ytse Noppe, Liesbet Termote, Sofie De Braekeleer, Jerel Vega, Ellen Van Gulck, Sarah Gerlo, Linos Vandekerckhove
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57332-5

Internet

https://doi.org/10.1038/s41467-025-57332-5

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