Mechanically interlocked molecular architectures of valinomycin as cancer targeted prodrugs

Abstract Macrocyclic drugs are promising agents for treating a variety of diseases. However, these compounds usually present delivery limitations, such as low tissue selectivity and poor cellular uptake, which may impair efficacy and clinical translation. Here, we propose a molecular machine approac...

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Bibliographic Details
Main Authors: Yoshihiro Tachihara, Yasuhiro Nakagawa, Takuya Miyazaki, Yasutaka Anraku, Horacio Cabral
Format: Article
Language:English
Published: Wiley-VCH 2022-08-01
Series:Nano Select
Subjects:
Online Access:https://doi.org/10.1002/nano.202100368